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Stephen B. Trippel, M.D.

Clinical Interests:
Arthritis treatment, joint preserving and joint replacement surgery.

Research Interests:
Development of new approaches to the treatment of articular cartilage damage, including tissue engineering and gene therapy.

Board Certification:
American Board of Orthopaedic Surgery, 1982

Education:
MD: Columbia University College of Physicians and Surgeons, New York , NY
Residency:  Harvard Medical School , Boston , Massachusetts

Fellowship:
Research Fellow, Orthopaedic Surgery, Massachusetts General Hospital , Boston , Massachusetts
Research Fellow, Pediatric Endocrinology, University of North Carolina School of Medicine , Chapel Hill , North Carolina

Publications:
Dr. Trippel is the author of more than 40 journal articles and numerous book chapters.

Honors, Awards and Recognitions:
Deputy Editor, Journal of Orthopaedic Research
Editorial Board, Orthopaedic Research and Reviews
Editorial Board, Editor for Orthopaedics, Contemporary Inflammation, Autoimmunity, Arthritis, Orthopaedics and Osteoporosis website
2003 - 2004 President, Orthopaedic Research Society
2004 Space Act Award, NASA
2004 21 st Century Fund Award, State of Indiana
2004 - 2006 Chair, Task Force on Clinical Research, American Orthopaedic Association

Current Academic Appointments:
2001 - Professor, Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis , Indiana

Appointment Scheduling:
317-274-7372

  1. Trippel SB , Ehrlich MG, Lippiello L, Mankin HJ: 1980 Characterization of chondrocytes from bovine articular cartilage. J. Bone Joint Surg., 62A:816-820.
  2. Trippel SB , Van Wyk JJ, Foster MB , Svoboda ME: 1983 Characterization of a specific somatomedin-C receptor on isolated bovine growth plate chondrocytes. Endocrinology 112:2128-36.
  3. Trippel SB : 1986 Antibiotic impregnated cement in total joint arthroplasty. J. Bone Joint Surg. 68A:1297-1302.
  4. Trippel SB , Van Wyk JJ, Mankin HJ: 1986 Localization of somatomedin-C binding to bovine growth plate chondrocytes in situ . J. Bone Joint Surg. 68A:897-903.
  5. Trippel SB , Chernausek SD , Van Wyk JJ, Moses AC, Mankin HJ: 1988 Demonstration of type I and type II somatomedin receptors on bovine growth plate chondrocytes. J. Orthop Res. 6:817-826.
  6. Trippel SB : 1988 Growth plate regulation: The somatomedins. Path and Immunopath Res. 7:43-47.
  7. Osborn KD, Trippel SB , Mankin HJ: 1989 Growth factor stimulation of adult articular cartilage. J. Orthop. Res. 7:35-42.
  8. Bell RS, Bell DF, Jacobs, J, Trippel SB , Gebhardt MC, Mankin HJ: 1989 Growth factor production by sarcoma cells in primary culture. J. Orthop. Res. 7:468-473.
  9. Trippel SB , Corvol MT , Dumontier MF, Rappaport R, Hung HM, Mankin HJ: 1989 Effect of somatomedin-C/insulin-like growth factor I on cultured growth plate and articular chondrocytes. Pediatric Res. 25:76-82.
  10. Trippel SB : 1990 Articular cartilage research. Current Opinion in Rheumalogy. 2:777-782
  11. Trippel SB : 1990 Basic science of the growth plate. Current Opinion in Orthopaedics 1:279-288
  12. Mankin HJ, Jennings LC, Treadwell BV , Trippel SB : 1991 Growth factors and articular cartilage. J Rheumatol (Suppl 27) 18:66-7.
  13. Carpenter JE, Hipp JA, Gerhart TN , Rudman CG, Hayes WC, Trippel SB : 1992 Failure of growth hormone to alter fracture healing biomechanics in a rabbit model. J Bone Joint Surg. 74-A:359-367.
  14. Trippel SB , Whelan MC, Klagsbrun M, Doctrow SR: 1992 Interaction of basic fibroblast growth factor with bovine growth plate chondrocytes. J Orthop Res. 10:638-4646.
  15. Trippel SB , Wroblewski J, Makower A-M, Whelan MC, Schoenfeld D, Doctrow SR:1993 Regulation of growth plate chondrocytes by insulin-like growth factor I and basic fibroblast growth factor. J Bone Joint Surg 75-A:177-189.
  16. Sah RL, Grodzinsky AJ, Trippel SB : 1994 Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys 308:137-147.
  17. Lynch SE, Trippel SB , Finkelman RD, Hernandez RA, Kiritsy CP, Antoniades HN: 1994 The combination of platelet-derived growth factor-BB and insulin-like growth factor-I stimulates bone repair in adult Yucatan micro pigs. Wound Repair Regen. 2:182-190.
  18. Seong S-C, Matsumura T, Lee FY, Whelan MC, Li X-Q, Trippel SB : 1994 Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture. Exp Cell Res 211:238-244.
  19. Sandell LJ, Sugai JV, Trippel SB : 1994 Expression of collagens I, II, X and XI and aggrecan mRNAs by bovine growth plate chondrocytes in situ . J Orthop Res 12:1-14.
  20. Trippel SB : 1995 Growth factor actions on articular cartilage. J Rheumatol (Suppl 43) 22:129-132.
  21. Sah RL, Trippel SB , Grodzinsky AJ: 1996 Differential effects of serum, IGF-I and FGF-2 on the maintenance of cartilage properties during long-term culture. J Orthop Res. 14:44-52.
  22. Trippel SB , Coutts RD , Einhorn TA, Mundy GR, Rosenfeld R: 1996 Instructional Course Lectures: Growth factors as therapeutic agents. J Bone Joint Surg 78A:1272-1286.
  23. Bonassar LJ, Trippel SB : Interaction of epidermal growth factor and insulin-like growth factor-I in the regulation of growth plate chondrocytes. Exp Cell Res., 1997.
  24. Trippel SB : 1998 Potential role of insulin-like growth factors in fracture healing. Clin Orthop. 3555: 5301-5313.
  25. Fraenkel L, Zhang Y, Trippel SB , McAlindon TE, LaValley MP, Assif A, Adams KE, Evans SR, Felson DT: 1998 Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis. Osteoarthritis and Cartilage. 6:362-367.
  26. Garcia AM, Lark MW, Trippel SB , Grodzinsky, AJ: 1998 Transport of tissue inhibitor of metalloproteinase-1 through cartilage: Contributions of fluid flow and electrical migration. J. Orthop Res. 16: 734-742.
  27. Trippel SB : 1999 The unmet anti-inflammatory needs in orthopedics. Amer. J. Orthop. 28:3-7.
  28. McGibbon CA, Krebs DE, Trahan CA, Trippel SB , Mann R: 1999 Cartilage degeneration in relation to repetitive pressure. J Arthroplasty 14: 52-58.
  29. Matsumura T, Whelan M, Li XQ, Trippel SB : 2000 Regulation by IGF-I and TGF- b 1 of Swarm rat chondrosarcoma chondrocytes. J Orthop Res 18:351-355.
  30. Madry H, Trippel SB : 2000 Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Therapy 7:286-291
  31. Bonassar LJ, Grodzinsky AJ, Srinivasan A, Davila SG, Trippel SB : 2000 Mechanical and physicochemical regulation of the action of insulin-like growth factor-I in articular cartilage. Arch Biochem Biophys. 379:57-63
  32. Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktar NR, Trippel SB : 2001 The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop. Res. 19; 11-17.
  33. Madry H, Zurakowski D, Trippel SB : 2001 Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Therapy 8: 1443-1449.
  34. Madry H, Padera R, Seidel J, Langer R, Freed, LE, Trippel SB , Vunjak-Novakovic, G: 2002 Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Human Gene Therapy 13: 1621-1630.
  35. Madry H, Cucchiarini M, Terwilliger EF, Trippel SB : 2003 Recombinant adeno-associated vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Human Gene Therapy 14: 393-402.
  36. Garcia AM, Szasz N, Trippel SB , Morales TI, Grodzinsky AJ, Frank EH: 2003 Transport and binding of IGF-I through articular cartilage. Arch Biochem Biophys. 415: 69-79.
  37. Madry H, Cucchiarini M, Stein U, Remberger K, Menger MD, Kohn D, Trippel SB : 2003 Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med. 5 (6): 502-509.
  38. Jin M, Emkey GR, Siparsky P, Trippel SB , Grodzinsky AJ: 2003 Combined effects of insulin-like growth factor-I on chondrocyte biosynthesis in cartilage explants. Arch Biochem Biophys. 414: 223-231.
  39. Fanning PJ, Emkey G, Smith RJ, Grodzinsky AJ, Szasz N, Trippel SB : 2003 Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem. 278: 50940-50948.
  40. Trippel SB : 2003 Current Issues in Orthopaedics. Business Briefing. Global Surgery 2003: 24-32.
  41. Trippel SB , Ghivizzani SC, Nixon AJ: 2004 Gene-based approaches for the repair of articular cartilage. Gene Therapy. 11: 351-359.
  42. Madry H, Emkey G, Zurakowski D, Trippel SB : 2004 Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocytes transplantation. J Gene Med. 6: 238-245.
  43. Trippel SB : 2004 Growth factor inhibition: Potential role in the etiopathogenesis of osteoarthritis. Clin Orthop. 427S:S47-S52.
  44. Madry H, Cucciarini M, Kaul G, Kohn D, Terwilliger EF, Trippel SB : 2004 Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo. Amer J Sports Med. 32:1860-1865.
  45. Cucciarini M, Madry H, Ma C, Thurn T, Zurakowski D, Menger MD, Kohn D, Trippel SB, Terwilliger EF:  2005 Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2.  Molecular Therapy 12:229-238.
  46. Madry H, Kaul G, Cucchiarini M, Stein U, Zurakowski D, Remberger K, Menger M, Kohn D, and Trippel SB : 2005 Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Therapy 12:1171-1179.
  47. McMaster WC, Sale, K, Anderson G, Bostrom M, Gebhardt MC, Trippel, SB, Clark DC:  2006 The conduct of clinical research under the HIPAA privacy rule. J Bone Joint Surg 88-A-2765-2770.
  48. Trippel SB, Cucciarini M, Madry H, Shi S, Wang C:  2007 Gene therapy for articular cartilage repair. J Engineering in Medicine  221, Part H:451-459.
  49. Takahashi T, Morris E, Trippel SB:  2007 Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth facture-I with growth plate chondrocytes. International Journal of Molecular Medicine 20:53-57
  50. Trippel, SB, Bosse MJ, Heck DA, Wright JG:  2007 How to participate in orthopaedic randomized clinical trials. J Bone Joint Surg 89-A:1856-1864.
  51. AAOS Technology Assessment Task Force: 2008 Gender-specific knee replacement: A technology overview. Journal of the American Academy of Orthopaedic Surgery, 16:63-67.
  52. Shi S, Mercer S, Dilley R, Trippel SB:  2009 Production of recombinant AAV vectors encoding insulin-like growth factor I is enhanced by interaction among AAV rep regulatory sequences. Virology Journal 6:3; DOI:10.1186/1743-422X-6-3.
  53. Shi S, Mercer S, Eckert G, Trippel SB:  2009 Growth factor regulation of growth factors by articular chondrocytes.  J Biol Chem; DOI:10.1074/jbc.M80785920.
  54. Shi S, Mercer S, Trippel SB:  2010 Effect of transfection strategy on growth factor overexpression by articular chondrocytes.  J Orthop Res; DOI:10.1002/jor.20945.
  55. Shi S, Mercer S, Eckert G, Trippel SB:  2011 Regulation of Articular Chondrocyte Aggrecan and Collagen Gene Expression by Multiple Growth Factor Gene Transfer. J Orthop Res; DOI: 10.1002/jor.22036,
  56. Weimer A, Henning M, Venkatesan JK, Schmitt G, Frisch J, Wezel A, Jung J, Kohn D, Terwilliger EF, Trippel SB, and Cucchiarini M: 2011 Benefits of rAAV-Mediated IGF-I Overexpression for the Long-Term Reconstruction of Human Osteoarthritic Cartilage by modulation of the IGF-I Axis; Molecular Medicine; DOI: 10.2119/molmed.2011.00371


Book Chapters:

  1. Van Wyk JJ, Trippel SB: Endocrine, paracrine, and autocrine effects of the somatomedins/insulin-like growth factors. In: Isakkson O et al, eds. Growth hormone-basic and clinical aspects. Elsevier Science Publishers 1987.
  2. Trippel SB, Mankin HJ: Soft tissue trauma to joints and articular cartilage, and major tendon and ligament injuries. In: Boyd RJ, Burke JF, McCabe CJ, eds. Trauma Management, 2nd Edition. Chicago : Year Book Medical Publishers 1988.
  3. Trippel SB: Hip and Thigh Injuries. In: May HJ, ed. Emergency Medicine, 2nd Edition. Boston . Little Brown. 1992:825-838.
  4. Howell DS, Treadwell BV , Trippel SB: Etiopathogenesis of osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, eds. Osteoarthritis, 2nd edition. Philadelphia . WB Saunders. 1992:233-252.
  5. Trippel SB: Role of insulin-like growth factors in the regulation of chondrocytes. In: Adolphe M, ed. Biological Regulation of the Chondrocyte. Boca Raton . CRC Press. 1992:161-190.
  6. Trippel SB, Mankin HJ: Articular cartilage healing. In: Bojrab J, ed. Mechanisms of Surgical Diseases of Small Animals, 2nd edition. Philadelphia : Lea and Febiger. pp 711-726, 1993.
  7. Trippel SB, Mankin HJ: Articular Cartilage Injury and Repair. In: Siliski J, ed. Traumatic Disorders of the Knee. New York , N.Y. Springer-Verlag, 1994:19-36.
  8. Trippel SB: Biologic regulation of bone growth. In: Brighton CT , Friedlander G, Lane JM, eds. Bone Formation and Repair, Rosemont , IL : American Academy of Orthopaedic Surgeons, 1995: Chapter 4, 39-60.
  9. Trippel SB, Mankin HJ: The Healing of Injury: Articular Cartilage. In: Gregg PT, Stevens J, Worlock PH, eds. Fractures and Dislocations: Principles of Management. London : Blackwell Scientific Publications 1996:79-86.
  10. Trippel SB: Growth factors as therapeutic agents. In: Springfield DS, ed. Instructional Course Lectures, Rosemont , IL . American Academy of Orthopaedic Surgeons. 1997:46:473-476.
  11. Einhorn TE, Trippel SB: Growth factor treatment of fractures. In: Springfield DS, ed. Instructional Course Lectures, Rosemont , IL . American Academy of Orthopaedic Surgeons. 1997:46:477-482.
  12. Trippel SB, Rosenfeld RG: Growth factor treatment of disorders of skeletal growth. In: Springfield DS, ed. Instructional Course Lectures, Rosemont , IL . American Academy of Orthopaedic Surgeons. 1997:46:483-486.
  13. Trippel SB: Role of IGF-I and FGF-2 in growth plate regulation. In: Buckwalter JA, Ehrlich MG, Sandell LJ, Trippel SB, eds. Skeletal Growth and Development: Clinical Issues and Basic Science Advances, Rosemont , IL . American Academy of Orthopaedic Surgeons. 1998:263-283.
  14. Trippel SB: Growth factor regulation of osteogenesis. In: Lieberman JR and Friedlaender GE, eds. Bone Regeneration and Repair: Biology and Clinical Applications, Totowa , NJ . Humana Press. 2005:113-132.

    Published Books

    Buckwalter JA, Ehrlich MG, Sandell LJ, Trippel SB, eds. Skeletal Growth and Development: Clinical Issues and Basic Science Advances. Rosemont , IL , American Academy of Orthopaedic Surgeons. pp 263-283, 1998